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Minimally psychoactive plants which contain mainly caffeine and theobromine

List of psychoactive plants

Minimally psychoactive plants which contain mainly caffeine and theobromine:

cocoa
coffee
guarana (caffeine in guarana is sometimes called guaranine)
kola
tea (caffeine in tea is sometimes called theine) – also contains theanine
yerba mate (caffeine in yerba mate is sometimes called mateine)
Most known psychoactive plants:

cannabis: cannabinoids
coca: cocaine
kava: kavalactones
khat: cathine and cathinone
nutmeg: myristicin and elemicin
opium poppy: morphine, codeine, and other opiates
salvia divinorum: salvinorin A
tobacco: nicotine and beta-carboline alkaloids
Solanaceae plants—contain atropine, hyoscyamine, and scopolamine:

datura
deadly nightshade Atropa belladonna
henbane
mandrake (mandragora)
other Solanaceae
Cacti with mescaline:

Peyote
Trichocereus macrogonus, the Peruvian torch cactus, and in particular its variety T. macrogonus var. pachanoi, the San Pedro cactus
Other plants:

Areca catechu (see: betel and paan)—arecoline
Ayahuasca (for DMT)
Calea zacatechichi
damiana
ephedra: ephedrine
kratom: mitragynine, mitraphylline, 7-hydroxymitragynine, raubasine, and corynanthine
Morning glory and Hawaiian Baby Woodrose – lysergic acid amide (LSA, ergine)
Rauvolfia serpentina: rauwolscine
Silene capensis
Tabernanthe iboga (“Iboga”)—ibogaine
valerian: valerian (the chemical with the same name)
various plants like chacruna, jurema, vilca, and yopo – 5-MeO-DMT
yohimbe (Pausinystalia johimbe): yohimbine and corynanthine
many others
Fungi:

various Amanita mushrooms: muscimol
Amanita muscaria: ibotenic acid and muscimol
Claviceps purpurea and other Clavicipitaceae: ergotamine (not psychoactive itself but used in synthesis of LSD)
psilocybin mushrooms: psilocybin and psilocin
Psychoactive animals:

hallucinogenic fish
psychoactive toads: Bufo alvarius (Colorado River toad or Sonoran Desert toad) contains bufotenin (5-MeO-DMT)

Law and policy

Approaches
Demand reduction
Harm reduction
Supply reduction
Alcohol licensing laws of the United Kingdom
Ban on caffeinated alcoholic drinks in the United States
Drug policy
Drug checking
Drug education
Drug liberalization
Prohibition of drugs
Drug rehabilitation
Drug addiction recovery groups
Native American temperance activists
Sober living environment
Illegal drug trade
Legalization of non-medical cannabis in the United States
Over the counter drug
Regulation of therapeutic goods
Pharmacology
Effective dose
Effects of cannabis
Median lethal dose
Psychopharmacology
Psychotomimetism
Toxicity

Health risks

Main articles: Addiction, Substance abuse, and Substance use disorder

A 1914 photo of intoxicated men in a sobering-up room
Further information: Addiction vulnerability, Alcohol intoxication, and Drug overdose

Radar plot of 20 widely used recreational drugs by dependence likelihood and physical and social harms
The severity of impact and type of risks that come with recreational drug use vary widely with the drug in question and the amount being used. There are many factors in the environment and within the user that interact with each drug differently. Alcohol is sometimes considered one of the most dangerous recreational drugs. Alcoholic drinks, tobacco products and other nicotine-based products (e.g., electronic cigarettes), and cannabis are regarded by various medical professionals as the most common and widespread gateway drugs. In the United States, Australia, and New Zealand, the general onset of drinking alcohol, tobacco smoking, cannabis smoking, and consumption of multiple drugs most frequently occurs during adolescence and in middle school and secondary school settings.

Some scientific studies in the early 21st century found that a low to moderate level of alcohol consumption, particularly of red wine, might have substantial health benefits such as decreased risk of cardiovascular diseases, stroke, and cognitive decline. This claim has been disputed, specifically by British researcher David Nutt, professor of neuropsychopharmacology at the Imperial College London, who stated that studies showing benefits for “moderate” alcohol consumption in “some middle-aged men” lacked controls for the variable of what the subjects were drinking beforehand. Experts in the United Kingdom have suggested that some psychoactive drugs that may be causing less harm to fewer users (although they are also used less frequently in the first place) are cannabis, psilocybin mushrooms, LSD, and MDMA; however, these drugs have risks and side effects of their own.